Diversity of MHC Genes in the 1000 Genomes Dataset

Authors: Tünde Vágó, Péter Tóth, Tim Hague, Szilveszter Juhos Introduction: The 1000 Genomes Project (1KG) was the first large-scale sequencing project to obtain comparable whole genome sequences from diverse human populations. Previously we validated our HLA typing method using these datasets for Class-II and Class-II HLA genes for 3 fields accuracy. Furthermore, using...

 

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Whole-Gene Next-Generation Sequencing of HLA Genes Reveals Hidden Diversity of Intronic Regions

Authors: György Horváth, Krisztina Rigó, Tim Hague, Szilveszter Juhos Introduction: Intronic regions of HLA alleles are less studied, but with the help of modern NGS kits covering whole genes it is easier to investigate this relatively unknown domain of sequences. To reveal the diversity of these regions we are presenting the comparison...

 

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