NGS rEvolution – Minimal Residual Disease Detection <=> Maximal Relapse Prevention

Development of techniques in molecular biology over the last couple of years has not influenced only rEvolution (revolution + evolution) in HLA typing but also in other segments of onco-diagnostics and transplant medicine. Evaluation and implementation of Next Generation Sequencing (NGS) technology in Minimal Residual Disease (MRD) detection and...

 

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Mortality Prediction Hidden in our Genome

The success of hematopoietic stem cell transplant (HSCT) is influenced by many factors including HLA mismatches, variations in the major histocompatibility complex (MHC) region, minor histocompatibility targets of allorecognition, regulatory elements that affect gene expression and genetic variation that affects immune responses (Table 1, Table 2). The individual contribution...

 

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