Should the best mismatched donor be chosen based on KIR typing? KIR role in transplantation and implications

29/06/2020

Written by Vera Siffnerová (FAS, Omixon) A choice of the most suitable donor for each transplant patient has always been the main focus and challenge for the whole team that is involved in the selection process. There is a high number of criteria that are evaluated, different approaches and...

How Genetic Variation in the Immune System Predicts COVID-19 Disease Outcome

23/03/2020

Authors: Csaba Pal, Mate Manczinger, Attila Berces As we all know, the COVID-19 infectious disease caused by the SARS-CoV2 virus has spread globally. It is a significant and urgent medical threat with serious implications on our personal life and global economy. Therefore, it is of paramount importance to identify...

Loss of Heterozygosity – “Cancer Mimicry”

27/06/2019

Article written by Vera Siffnerova (FAS, Omixon) In most Slavic languages, LOH stands for Summer Olympic Games (e. g. Letní Olympijské Hry in Czech), in HLA world, LOH is known as an abbreviation of an important disease marker – Loss of Heterozygosity – during which different types of cancer...

Mortality Prediction Hidden in our Genome

26/02/2019

The success of hematopoietic stem cell transplant (HSCT) is influenced by many factors including HLA mismatches, variations in the major histocompatibility complex (MHC) region, minor histocompatibility targets of allorecognition, regulatory elements that affect gene expression and genetic variation that affects immune responses (Table 1, Table 2). The individual contribution...

It Is Not You Who Chooses Your Partner… But Your HLA Genes!

24/10/2018

Written by Nina Lauterbach, PhD (Field Application Scientist, Omixon) Animals, and us humans, are daily under attack by viruses and other pathogens. Fortunately, we are equipped with the Major Histocompatibility Complex (MHC) as an efficient and adaptable fighting mechanism to deal with these threatening events. This complex is encoded...