Whole-Gene Next-Generation Sequencing of HLA Genes Reveals Hidden Diversity of Intronic Regions

06/05/2015

Authors: György Horváth, Krisztina Rigó, Tim Hague, Szilveszter Juhos Introduction: Intronic regions of HLA alleles are less studied, but with the help of modern NGS kits covering whole genes it is easier to investigate this relatively unknown domain of sequences. To reveal the diversity of these regions we are presenting the comparison...

High Accuracy and High Precision HLA Typing Using Illumina Reads: Typing Algorithm and Perspectives on Novel Allele Discovery

24/02/2015

Authors: György Horváth, Krisztina Rigó, Tim Hague, Attila Bérces, Szilveszter Juhos Abstract: Wide acceptance of high-throughput next-generation sequencers in medicinal genomics and clinics brought the promise of fast HLA typing. We are presenting the algorithmic challenges and workflow of HLA typing with a special attention to ambiguous or poorly...

Immunotherapy

07/01/2015

Cancer has become one of the biggest killers in the western world. High profile campaigns to tackle breast cancer and other common types have ensured that it is also one of the biggest businesses in modern medicine. To fight a high profile killer you need the best of cures....

Omixon at This Year’s BSHI Conference

10/09/2014

Arnold Feher and Tim Hague attended the BSHI conference in Manchester. There was a very interesting series of talks about the state of transplantation in the UK, plus a trade show, poster exhibition and some lunchtime presentations from the corporate sponsors concentrating on the use of NGS for HLA....